Baritone and lap steel guitars are introduced by the band on multiple tracks, in addition to the electric and acoustic guitars typically used by the band, as well as a variety of percussion instruments, including rotary timpani and vibraphones. Instrumentally, it incorporates vintage synthesisers and keyboards, including organs, pianos, harpsichords and the dolceola, as well as the Orchestron, Farfisa and RMI Rocksichord. It also draws influence from soul, progressive rock, funk, French pop and film soundtracks of the 1960s. It features a rich sound that embodies psychedelic pop, lounge pop, space pop, and glam rock, as well as elements of jazz. Tranquility Base Hotel & Casino is a major departure from the band's previous guitar-heavy work, being considered less accessible than its internationally successful predecessor, AM (2013). Its title refers to Tranquility Base, the site of the 1969 Apollo 11 Moon landing. Turner designed the album artwork himself, which depicts the eponymous resort with cardboard cut-outs and a tape recorder.

It was produced in Los Angeles, Paris and London by frequent Arctic Monkeys collaborator James Ford and Turner, alongside a wide array of guest musicians including Tom Rowley, Loren Humphrey, James Righton, Zach Dawes, Tyler Parkford and Cam Avery. The album was written by frontman Alex Turner in 2016 on a Steinway Vertegrand piano in his Los Angeles home.

Tranquility Base Hotel & Casino (stylised as Tranquility Base Hotel + Casino) is the sixth studio album by English rock band Arctic Monkeys, released on by Domino Recording Company.

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